Metformin XR 500 — questions and safety.
Back to Metformin XR 500Common (Typically transient):
• Nausea
• Diarrhea
• Gas or bloating
• Metallic taste
Less Common / Monitor If Present:
• Vitamin B12 deficiency (check annually)
• Lactic acidosis (rare; risk higher in kidney/liver impairment or alcohol abuse)
• Decreased appetite or mild fatigue
Precautions:
Not recommended in patients with eGFR <30 mL/min
Caution with alcohol or severe calorie restriction
Monitor B12 annually with long-term use
Take with food to reduce GI side effects
• Start with 500mg once daily, gradually titrate up to 1000–2000mg daily if tolerated
• Week 1–2: Improved blood sugar and appetite control
• Week 4+: Enhanced energy, fat loss, cognitive clarity
• Full anti-aging and metabolic benefits seen with consistent, long-term use
• Best when combined with fasting, low-glycemic nutrition, and exercise
• Missed dose? Skip and resume at the next scheduled time—do not double up
Tablets in a bottle
Yes, on every order. A physician licensed in your state reviews your intake before anything is prescribed.
Most treatments ship within 3 days of your clinician's approval. Timing can vary with your provider's review and the pharmacy filling your prescription. Shipping is free and the packaging is plain.
Any time. Dose, form and frequency are all adjustable, and changing costs nothing.
Any time, from your account. No call, no retention offer.
1010Rx, LLC works with a network of licensed dispensing pharmacy partners to fulfill prescriptions written by clinicians on our platform. When a prescription is issued, it is routed to one of these partner pharmacies based on the medication prescribed, the patient’s state of residence, and availability. Each partner pharmacy is independently licensed and responsible for dispensing, labeling, and shipping the medication directly to the patient. Our current pharmacy partners, including the licensed entity name that will appear on your prescription label, may include:
- DrugStore on East State — The Drugstore at O’Bleness LLC, 934 E State St, Athens, OH 45701 · (740) 566-4690
- DiRx Health — Direct Pharmacy Source, Inc., 3540 NW 56th St, Ste 204, Fort Lauderdale, FL 33309 · (877) 367-3479
- Curexa — Curexa Pharmacy, 501 Zion Rd, Ste 13-14, Egg Harbor Township, NJ 08234 · (855) 927-0390
- Mycelium — Mycelium Pharmacy LLC, 141 E Commercial Blvd, Fort Lauderdale, FL 33334 · (954) 890-1150
- ChemistryRx — Madame Rx, LLC d/b/a Chemistry Rx, 950 Henderson Blvd, Folcroft, PA 19032 · (855) 790-0100
- Brooksville Rx — Brooksville Pharmaceuticals, 16140 Flight Path Dr, Brooksville, FL 34604 · (352) 848-3446
- Epiq Scripts — Epiq Scripts LLC, 465 W President George Bush Hwy, Ste 240, Richardson, TX 75080 · (833) 654-3553
- Foothills — Foothills Professional Pharmacy Ltd, 2727 W Baseline Rd, Ste 1, Tempe, AZ 85283 · (833) 236-8080
- Southend — Southend Pharmacy, 4802 N Sam Houston Pkwy W, #100, Houston, TX 77086 · (855) 414-5356
- Wells — Wells Pharmacy Network, 3420 Fairlane Farms Rd, Wellington, FL 33414 · (800) 622-4510
Certain branded medications are fulfilled through manufacturer self-pay programs rather than our pharmacy network. These include NovoCare Pharmacy (CoAssist Pharmacy, LLC, 2400 Sand Lake Rd, Ste 200B, Orlando, FL 32809 · (833) 949-5527) and LillyDirect (GiftHealth, Inc., 266 N 4th St, Ste 200, Columbus, OH 43215 · (833) 614-4438).
This list may change from time to time.
Full safety information
Common (Typically transient):
• Nausea
• Diarrhea
• Gas or bloating
• Metallic taste
Less Common / Monitor If Present:
• Vitamin B12 deficiency (check annually)
• Lactic acidosis (rare; risk higher in kidney/liver impairment or alcohol abuse)
• Decreased appetite or mild fatigue
Precautions:
Not recommended in patients with eGFR <30 mL/min
Caution with alcohol or severe calorie restriction
Monitor B12 annually with long-term use
Take with food to reduce GI side effects
Prescription items are subject to clinician review before dispensing. After checkout you will complete a medical intake form. A licensed physician reviews it, and if you are approved, your medication ships. Your clinician sets the exact dose during that review.
This is a prescription product and requires an evaluation by a licensed provider. Purchase does not guarantee a prescription, and if you are not approved you will not be charged for medication.
Availability varies by state. Not for use by anyone under 18. This information is not medical advice — talk to your provider about risks, side effects and interactions.
Multi-month plans renew automatically at the end of the term until cancelled. Cancel any time before renewal from your account.