Semaglutide — questions and safety.

Common

Nausea

Diarrhea

Vomiting

Constipation

Abdominal pain or discomfort

Headache

Fatigue

Indigestion, belching, or bloating

Serious / Contact Your Healthcare Provider

Severe or persistent abdominal pain, which may be a sign of pancreatitis

Symptoms of gallbladder problems, such as upper abdominal pain, fever, or yellowing of the skin or eyes

Persistent vomiting or diarrhea, dehydration, or signs of kidney problems

Symptoms of a serious allergic reaction

Changes in vision, particularly in patients with diabetes

Symptoms of low blood sugar when used with insulin or certain other diabetes medications

Severe or persistent gastrointestinal symptoms

Semaglutide carries a boxed warning related to thyroid C-cell tumors observed in rodents. It should not be used in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Patients should discuss neck masses, persistent hoarseness, trouble swallowing, or other concerning symptoms with their healthcare provider.

Tell your healthcare provider if you are pregnant, planning pregnancy, breastfeeding, have a history of pancreatitis or gallbladder disease, have significant gastrointestinal problems, or take medications for diabetes. Semaglutide should be discontinued at least 2 months before a planned pregnancy because of its long washout period.

Because semaglutide delays gastric emptying, tell healthcare professionals that you use semaglutide before surgery or procedures requiring anesthesia or deep sedation.

Compounded semaglutide products can differ in concentration and packaging. Follow the pharmacy label and prescriber’s directions exactly. Do not convert milligrams, milliliters, or syringe “units” without specific instructions from the prescriber or dispensing pharmacy.

Weeks 1–4

Treatment commonly begins with a lower prescribed dose to improve gastrointestinal tolerability. Appetite may begin to decrease, while nausea, fullness, constipation, diarrhea, or other gastrointestinal effects may occur as the body adjusts.

Weeks 5–8

If tolerated and prescribed, the dose may be increased gradually. Patients may notice more consistent appetite control and earlier fullness. Weight response varies and should be evaluated along with nutrition, activity, tolerability, and overall health.

Weeks 9–16 and Beyond

Ongoing treatment may support continued weight-management progress when combined with a reduced-calorie eating pattern, physical activity, and medical follow-up. The appropriate dose and duration are individualized by the prescriber.

Use the medication exactly as directed and keep scheduled follow-up appointments so the healthcare team can assess response, side effects, and whether dose adjustments are appropriate.

If a dose is missed, follow the instructions provided by the prescriber and dispensing pharmacy. Do not take extra medication or change the dose to make up for a missed dose unless specifically directed.

Subcutaneous Injection

Yes, on every order. A physician licensed in your state reviews your intake before anything is prescribed.

Most treatments ship within 3 days of your clinician's approval. Timing can vary with your provider's review and the pharmacy filling your prescription. Shipping is free and the packaging is plain.

Any time. Dose, form and frequency are all adjustable, and changing costs nothing.

Any time, from your account. No call, no retention offer.

1010Rx, LLC works with a network of licensed dispensing pharmacy partners to fulfill prescriptions written by clinicians on our platform. When a prescription is issued, it is routed to one of these partner pharmacies based on the medication prescribed, the patient’s state of residence, and availability. Each partner pharmacy is independently licensed and responsible for dispensing, labeling, and shipping the medication directly to the patient. Our current pharmacy partners, including the licensed entity name that will appear on your prescription label, may include:

• DrugStore on East State — The Drugstore at O’Bleness LLC, 934 E State St, Athens, OH 45701 · (740) 566-4690
• DiRx Health — Direct Pharmacy Source, Inc., 3540 NW 56th St, Ste 204, Fort Lauderdale, FL 33309 · (877) 367-3479
• Curexa — Curexa Pharmacy, 501 Zion Rd, Ste 13-14, Egg Harbor Township, NJ 08234 · (855) 927-0390
• Mycelium — Mycelium Pharmacy LLC, 141 E Commercial Blvd, Fort Lauderdale, FL 33334 · (954) 890-1150
• ChemistryRx — Madame Rx, LLC d/b/a Chemistry Rx, 950 Henderson Blvd, Folcroft, PA 19032 · (855) 790-0100
• Brooksville Rx — Brooksville Pharmaceuticals, 16140 Flight Path Dr, Brooksville, FL 34604 · (352) 848-3446
• Epiq Scripts — Epiq Scripts LLC, 465 W President George Bush Hwy, Ste 240, Richardson, TX 75080 · (833) 654-3553
• Foothills — Foothills Professional Pharmacy Ltd, 2727 W Baseline Rd, Ste 1, Tempe, AZ 85283 · (833) 236-8080
• Southend — Southend Pharmacy, 4802 N Sam Houston Pkwy W, #100, Houston, TX 77086 · (855) 414-5356
• Wells — Wells Pharmacy Network, 3420 Fairlane Farms Rd, Wellington, FL 33414 · (800) 622-4510

Certain branded medications are fulfilled through manufacturer self-pay programs rather than our pharmacy network. These include NovoCare Pharmacy (CoAssist Pharmacy, LLC, 2400 Sand Lake Rd, Ste 200B, Orlando, FL 32809 · (833) 949-5527) and LillyDirect (GiftHealth, Inc., 266 N 4th St, Ste 200, Columbus, OH 43215 · (833) 614-4438).

This list may change from time to time.