1010Rx
Longevity

Metformin XR 500

Tablet
Metformin XR 500

Metformin is a well-known oral medication traditionally used to manage type 2 diabetes.

Quantity
Select treatment cycle
Total due now$25
What’s included
  • Clinician consultation
  • Shipping, always free
  • The same price at every dose
  • Message your clinician any time

Prescription items are subject to clinician review before dispensing. After checkout you will complete a medical intake form. A licensed physician reviews it, and if you are approved, your medication ships. Your clinician sets the exact dose during that review.

This is a prescription product and requires an evaluation by a licensed provider. Purchase does not guarantee a prescription, and if you are not approved you will not be charged for medication.

Availability varies by state. Not for use by anyone under 18. This information is not medical advice — talk to your provider about risks, side effects and interactions.

Multi-month plans renew automatically at the end of the term until cancelled. Cancel any time before renewal from your account.

Full safety information

What you’re taking

Metformin XR 500
01 · Mechanism
Couple smiling at the camera

AMPK Activation

Metformin activates AMP-activated protein kinase (AMPK), a key energy sensor that promotes fat oxidation, glucose uptake, and mitochondrial biogenesis—mimicking the effects of fasting.

Man stretching at a stadium

Insulin Sensitivity & Glycemic Control

It lowers circulating insulin and glucose levels, helping reduce systemic inflammation and oxidative stress, two hallmarks of aging and metabolic decline.

Mature couple smiling together on the beach

mTOR Pathway Modulation

By inhibiting the mTOR pathway, Metformin slows down cellular overgrowth and supports autophagy—a crucial anti-aging process for cellular cleanup and repair.

Smiling woman in an orange jacket and knit cap
02 · Benefits

What it’s for

Enhances insulin sensitivity and stabilizes blood sugar

May reduce visceral fat and improve body composition

Supports mitochondrial function and metabolic flexibility

May reduce the risk of age-related diseases (heart disease, cancer, cognitive decline)

Activates cellular repair pathways (AMPK, autophagy)

Backed by decades of safety data

03 · Timeline

What to expect, and when

• Start with 500mg once daily, gradually titrate up to 1000–2000mg daily if tolerated

• Week 1–2: Improved blood sugar and appetite control

• Week 4+: Enhanced energy, fat loss, cognitive clarity

• Full anti-aging and metabolic benefits seen with consistent, long-term use

• Best when combined with fasting, low-glycemic nutrition, and exercise

• Missed dose? Skip and resume at the next scheduled time—do not double up

Person strolling in an autumn park
Two laboratory professionals in white coats reviewing results on a tablet beside a microscope

Same dose, different response

Your labs show why — and shape what comes next

Ferritin and ironthe most common reversible cause
Thyroidhair, skin and energy at once
Vitamin Ddeficiency is the default, not the exception
Testosterone and DHTthe hormonal side of the picture
hs-CRPinflammation, quietly
Liver and kidneywhat keeps your dosing safe
See the full panel

Also in Longevity