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Metformin

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Metformin

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What is Metformin?

Metformin is a well-known oral medication traditionally used to manage type 2 diabetes. In recent years, it has gained recognition in longevity and anti-aging medicine due to its impact on insulin sensitivity, mitochondrial health, inflammation, and cellular aging. As a caloric restriction mimetic, Metformin is now widely used off-label to support metabolic health, fat loss, and cellular resilience, with potential to reduce age-related diseases and improve health span.

How does it work?

Metformin targets multiple aging-related pathways through metabolic regulation and mitochondrial support:

  1. AMPK Activation
    • Metformin activates AMP-activated protein kinase (AMPK), a key energy sensor that promotes fat oxidation, glucose uptake, and mitochondrial biogenesis—mimicking the effects of fasting.
  2. Insulin Sensitivity & Glycemic Control
    • It lowers circulating insulin and glucose levels, helping reduce systemic inflammation and oxidative stress, two hallmarks of aging and metabolic decline.
  3. mTOR Pathway Modulation
    • By inhibiting the mTOR pathway, Metformin slows down cellular overgrowth and supports autophagy—a crucial anti-aging process for cellular cleanup and repair.

Benefits

✔ Enhances insulin sensitivity and stabilizes blood sugar

✔ May reduce visceral fat and improve body composition

✔ Supports mitochondrial function and metabolic flexibility

✔ May reduce the risk of age-related diseases (heart disease, cancer, cognitive decline)

✔ Activates cellular repair pathways (AMPK, autophagy)

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Frequently Asked Questions

Metformin helps your body process sugar more efficiently, which supports balanced energy and metabolic health. By reducing blood sugar spikes and improving insulin sensitivity, some patients find it easier to maintain a leaner, less bloated look over time.

It’s not a stimulant or a quick-fix weight loss drug. Instead, metformin supports the behind-the-scenes systems that influence weight, energy, and how your body responds to food.

Results are gradual and vary by individual. A prescription and medical evaluation are required.

Yes. Metformin is a prescription medication and must be prescribed by a licensed healthcare provider following a telehealth medical evaluation.

Metformin is not appropriate for all patients. Your provider will determine whether it’s a safe and appropriate option based on your medical history, goals, and current medications.

This information is for educational purposes only and does not replace medical advice. Individual results vary.

Metformin helps the body use insulin more efficiently and reduces excess sugar production in the liver. This may support:

  • Improved metabolic balance
  • Fewer blood sugar spikes and crashes
  • Reduced cravings for some patients
  • Easier consistency with healthy habits

Metformin works best when combined with nutrition, movement, and sleep.

Metformin may be appropriate for adults who:

  • Struggle with insulin resistance or blood sugar imbalance
  • Have stalled weight progress despite diet and exercise
  • Experience energy crashes or frequent sugar cravings
  • Want a non-GLP-1 metabolic support option
  • Are looking for a long-term, sustainable approach

Eligibility is determined by a licensed medical provider after a telehealth consultation.

Week 1–2: Improved blood sugar and appetite control

Week 4+: Enhanced energy, fat loss, cognitive clarity

• Full anti-aging and metabolic benefits seen with consistent, long-term use

• Best when combined with fasting, low-glycemic nutrition, and exercise

• Missed dose? Skip and resume at the next scheduled time—do not double up


This information is for educational purposes only and does not replace medical advice. Individual results vary. Metformin must be prescribed by a licensed healthcare provider following a telehealth consultation.

Common (Typically transient):
• Nausea
• Diarrhea
• Gas or bloating
• Metallic taste

Less Common / Monitor If Present:
• Vitamin B12 deficiency (check annually)
• Lactic acidosis (rare; risk higher in kidney/liver impairment or alcohol abuse)
• Decreased appetite or mild fatigue

Precautions:

  • Not recommended in patients with eGFR <30 mL/min
  • Caution with alcohol or severe calorie restriction
  • Monitor B12 annually with long-term use
  • Take with food to reduce GI side effects

Metformin is taken orally as a tablet. Providers often start with a low dose and gradually increase it to improve tolerance. Some patients are prescribed extended-release (ER) versions.